In modern pharmacology, G-protein coupled receptors (GPCRs) hold significant importance for cell communication. GPCRs comprise a large family of cell surface receptors that have the ability to respond to a large range of external stimuli. Due to this, more than 30% commercial drugs that are available in the global GPCRs market utilize and a large number of drugs that are in clinical and preclinical development stages target this receptor protein, which has been well-researched.
With the development of a large range of GPCR assays such as calcium level detection and cAMP type, drug discovery processes have been tremendously benefitted, for testing the ingredients and quality of the core content.
Assay Type and Therapeutic Area Segmentation of GPCRs Market
The global GPCRs market is segmented on the basis of assay type, therapeutic area, and geography. On the basis of assay type, cAMP, calcium detection, GTPγS, reporter gene, receptor internalization, and cGMP are the various segments of the market. Amongst all, it is the cAMP assay segment that led the global market in 2013. The growth of this segment is due to the usability of cAMP assays in high throughput screening (HTS), introduction of improved assays, discovery of several platforms for drug formulations, and wide usability of the assays in a host of therapeutic applications. cAMP assays were followed by calcium level detection assays.
The therapeutic area segments of the global GPCRs market are cardiovascular system, respiratory system, reproductive system, central nervous system (CNS), oncology, immune system, and others (urinary, abdominal, orthopedics, etc.). In 2013, oncology was the largest therapeutic area in the global GPCRs market. The segment comprises some of the prime cancer care therapeutic areas such as leukemia, cervical cancer, breast cancer, lung cancer, prostate cancer, and various other malignant tumorous protuberances, wherein GPCRs are used for drug clinical testing. With cancer recognized as one of the most lethal diseases and one that needs an urgent recuperative remedy, the global GPCR market will be benefitted in the years to come.
Prevalence of Harmful Lifestyles Benefits North America GPCRs Market
Geography-wise, the global GPCRs market has four broad regional segments, namely North America, Asia Pacific, Europe, and Rest of the World (RoW). Amongst all, North America currently dominates the global market for GPCRs. High geriatric population, high prevalence of cardiovascular diseases due to excessive smoking and alcohol consumption, and rising obesity due to unhealthy eating habits and sedentary lifestyle are some of the societal and demographic issues that the American society is grappling with. To cater to these problems, the pharmacology sector in the U.S. carries out extensive research initiatives for the testing and development of treatment and rehabilitation drugs. Hence, North America holds a large share in the GPCRs market.
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Europe is the second largest market for GPCRs. The region grapples with similar societal and demographic issues as North America, which need advanced drug formulations for remedial purposes. Currently, Asia Pacific is the third largest market for GPCRs and will exhibit the fastest growth in the coming years. Large untapped opportunities, increasing research and development initiatives, rising geriatric population, advancing healthcare infrastructure, and expanding operations of large pharmaceutical companies and CROs (contract research organizations) will collectively account for Asia Pacific’s rise as a significant market for GPCRs in the coming years.